 |
 |
 |
 |
 |
 |
Epithelial cell polarity is crucial for organogenesis, tissue patterning and organ functioning.
Cell polarity lab is a research group in Spain focused on the biology of epithelia. Since 2015, we have established our laboratory at University of Extremadura (UEX, www.unex.es). Our group led by Jose Maria Carvajal-Gonzalez, a Ramon y Cajal researcher, has vast experience in the study of epithelial cell biology in several model systems, including 2D and 3D model systems such as airway epithelial cells, kidney cells, retinal pigmented epithelial cells and keratinocytes.
Currently, we have two active lines of research in the laboratory. The first one covers our studies on organelles positioning and cell signaling in cells including airway epithelial cells differentiated in vitro. The second one aims to develop new quantitive tools and methods to study cell biology and development. All these lines of research had an intemate relationship with the development and regenerative biology of our respiratory system, but also with the interaction of our body with the surronding enviroment which might lead in some conditions to respiratory diseases including COPD (chronic obstructive pulmonary diseases).
Our specific skills:
1)-Respiratory tract cellular models in 2D cultures and organoids from mouse and human samples for diseases modeling or chemical testing.
2)-Functional analysis of the airway cellular models in 2D cultures and organoids including gene expression profile, cell populations, barrier function, mucus secretion, cellular morphology and histology.
3)-Quantitative cell biological analysis using computer vision and including ad hoc development of software.
